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Stop and Seek Help If Severe allergic reaction (rash, swelling, difficulty breathing) Persistent severe nausea or vomiting not improving with dose reduction Signs of pancreatitis (severe abdominal pain radiating to back) Planned pregnancy or positive pregnancy test Inability to maintain adequate nutrition despite dose adjustments Any concerning symptoms your healthcare provider advises stopping for Always consult your healthcare provider before stopping or modifying your dose

S., & Cha, H

Together, these observations suggest that circadian-regulated physiological signals play a direct and clinically meaningful role in shaping airway inflammation, yet the immune mechanisms underlying this temporal susceptibility remain incompletely understood

Murugan VA, Murphy BO, Dupuis C, Goldstein A, Kim YH

Concurrently, XO contributes to the production of reactive oxygen species (ROS)

This strategy supports prolonged immune stimulation and facilitates the development of durable memory T cells