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How Common Is Diarrhoea During Treatment Diarrhoea was reported in a dose-dependent manner in Phase 2 trials

Newer compounds like retatrutide add a third receptor target (GIP, GLP-1, and glucagon) and may create unique nutritional challenges that have not yet been well-studied

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Estradiol (transdermal route)

1 Several factors can cause reduced GLP-1 secretion, including overweight and obesity, sleep deprivation, chronic stress, and certain gut conditions, leading to significant dysregulation of appetite, insulin sensitivity, glucose regulation, and even cardiovascular and neurological processes

GLP-1 receptor agonists, such as semaglutide (Ozempic for type 2 diabetes