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Perioperative Opioids: Thoracic Surgery

A study that poses an important methodological issue on the possible detection bias induced by glucagon-like peptide 1 receptor agonist treatment

On 24 November 2025, Novo Nordisk reported that oral semaglutide had failed to slow Alzheimers disease in the EVOKE and EVOKE+ trials, which together enrolled 3,808 participants and stand as the largest evaluation of this drug class in any neurodegenerative condition [1]

Liraglutide is also more quickly eliminated from the body, which may make it inconvenient, as you would have to inject daily at consistent times to reach stable levels

The vast majority of patients are completely without any symptoms unless the nodule is so large that it is pressing against other structures in the neck, such as the esophagus making it hard or painful to swallow or larynx making it difficult to breathe

Instructions for use: Hold dose under the tongue for as long as possible