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Amino acids such as tryptophan, tyrosine, and phenylalanine are particularly susceptible, as described in ICH Q1B
This is why cost calculations must account for concentration, not just the milligram total on the label
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Small-molecule inhibitors such as MCC950 have shown efficacy in inhibiting NLRP3 activation and ameliorating liver injury in experimental models of APAP overdose
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